Biologic Activity of Tamoxifen at Low Doses in Healthy Women
نویسندگان
چکیده
منابع مشابه
Biologic activity of tamoxifen at low doses in healthy women.
BACKGROUND Results of a clinical trial recently completed in the United States indicate that administration of tamoxifen (20 mg/day) to women at risk can reduce breast cancer incidence by approximately 50% but is associated with an increased risk of developing endometrial cancer and venous thromboembolic events. Since these adverse effects may be dose related, we investigated the effect of tamo...
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Tamoxifen has been used as a treatment for women who have been diagnosed with breast cancer for roughly four decades and has been approved as chemoprevention for over ten years. Although tamoxifen has been proven to be beneficial in preventing breast cancer in high-risk women, its use has not been widely embraced. To some extent, this is due to several of its side effects, including an increase...
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Evidence supports a role of 17&-estradiol (E2) in carcinogenesis and the large majority of breast carcinomas are dependent on estrogen. The anti-estrogen tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer; however, it is also carcinogenic in human uterus and rat liver, highlighting the profound complexity of its actions. The nature of E2- or TAM-induced chromosoma...
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TO THE EDITOR: In their Newsline commentary, Drs. Feinendegen and Pollycove call an important issue to the attention of readers of The Journal of Nuclear Medicine (1). In a discussion of the dual action of ionizing radiation, they posit a competition at low doses between the direct induction of radiation damage and the activation of damage control (adaptive response, hormesis), such that below ...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 1998
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/90.19.1461